ABSTRACT
The toxic adverse effects of cisplatin administration on the liver of male albino rats were investigated. Congestion of blood vessels in the portal tracts and hemorrhage together with dilatation of the hepatic blood sinusoids were noticed. Cytoplasmic vacuolation of the liver cells was evident and started in the peripheral and middle zones of the hepatic lobules. Patches of hepatocyte necrosis showing remnants of cells and nuclei were demonstrated. A picture of confluent liver necrosis was recorded in the third week group. Nuclear changes in the liver cells varied between pyknosis, karyorrhexis and karyolysis. These changes were confirmed with Feulgen staining of DNA and morphometric studies that showed significant reduction in the nuclear surface area. Mononuclear cellular infiltration and increased profiles of the bile ducts were observed in some portal tracts. Depletion of the liver glycogen was noticed after cisplatin injection. Mitochondrial damage was obvious after treatment with the drug. The collagen content and the reticular fibers were increased in the portal tracts 2-3 weeks following drug administration